En effet les patients atteints de la maladie de Dupuytren notamment serait plus enclin à développer une maladie de Lapeyronie (l’association Dupuytren – maladie de lapeyronie a été retrouvée dans 10 à 15% des cas). See Table 1 for an explanation of the terms used in this study. Other than the common prevalence of DD in Scandinavia, no objective scientific evidence has been found to support and substantiate the “Nordic“ origin of this disease. It has been suggested that Dupuytren’s disease has an origin in Norse countries. To ensure that this method has power, we selected a positive control by repeating this analysis for a Lactase-associated SNP – rs4988235 in MCM6. La maladie de Dupuytren est une maladie génétique. It has been suggested that DD is a ‘disease of the Vikings’ (Flatt, 2001). Les modérateurs de ce forum sont des bénévoles et Dupuytren e.V. Elle a été décrite en 1831 par le baron Dupuytren, chirurgien à l'Hôtel-Dieu de Paris. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} La maladie de Dupuytren a été décrite par le Baron Dupuytren en 1832. This is contrast to the lactase-associated SNP rs4988235, which as expected shows a highly significant decrease in population-specific haplotype sharing (p < 0.001, Figure 2(b)). Townley, WA, Baker, R, Sheppard, N, Grobbelaar, AO. La contracture de Dupuytren est un état graduel qui influence les doigts et les mains, entraînant au moins un doigt, et probablement plusieurs, à courber vers la paume de la main. Next, to assess for localized population structure at the DD-associated loci in the PoBI dataset, we used chromosome painting, comparing the frequency of haplotypes most recently shared within population groups to that between population groups (Lawson et al., 2012). Create a link to share a read only version of this article with your colleagues and friends. La maladie de Dupuytren est une maladie évolutive, dont la vitesse d’évolution peut aller de quelques mois à plusieurs années. It is believed that this hand deformity originated with the Vikings and they spread it in Northern Europe and far beyond as they married the locals when travelling around the world. History of Dupuytren – Dupuytren Research Group, Dupuytren Disease and the Dupuytren Research Group, How is it staged or graded? Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. Elles s … We hypothesized that if DD was caused in individuals by having Norse ancestry at these loci, then we would expect that they have an excess amount of local structure, relative to the genome as a whole. Cette vidéo traite de la maladie de Dupuytren: et des soins naturels les plus efficaces à mettre en oeuvre dès l"apparition des troubles. Dupuytren’s Contracture is known by other names including Viking’s Disease and Baron Dupuytren’s Disease. Dupuytren's disease: what dermatologists need to know. Elle touche les aponévroses, c’est à dire les enveloppes fibreuses situées entre la peau et les tendons fléchisseurs de la main. Dupuytren's disease typically starts at the age of 50 to 60, though even children have been reported to suffer from Dupuytren's disease (example of a 10 year old boy: "Dupuytren's disease in a child: a case report" Dupuytren_child_abstract). Happy Holidays from the Dupuytren Research Group! Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Copyright © 2002 by the … Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). The People of the British Isles (PoBI) Study sampled DNA from 2039 individuals throughout rural areas of the UK whose four grandparents were born within 80 km of each other (Winney et al., 2012). (J Hand Surg 2002;27A:385–390. Elle est liée à un épaississement de l’aponévrose palmaire. View or download all content the institution has subscribed to. The mean difference in total FST between cases and controls ranged between −0.06 and 0.05 (Table 2). Maladie de Dupuytren La maladie de Dupuytren est une affection de la main caractérisée par une flexion progressive et irréductible de certains doigts. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. To make a fair null hypothesis, we sampled the same number of random genome-wide SNPs that make up the risk score using 500 random samples of 21 SNPs. En 1831, Guillaume Dupuytren était considéré comme le plus grand chirurgien d’Europe ().Sa présentation orale d’un cas de « rétraction des doigts par suite d’une affection de l’aponévrose palmaire » eut un retentissement immédiat en France et en Angleterre et fut à l’origine d’une polémique sur son étiologie et son traitement qui n’est pas encore terminée. L'héritage viking (3) : Les Vikings n’ont pas laissé que des vestiges archéologiques. The recruitment, genotyping, imputation and analysis methods for the BSSH-GODD and PoBI studies have been previously described (Leslie et al., 2015; Ng et al., 2017). Origines et signes de la maladie. Dupuytren's contracture (also called Dupuytren's disease, Morbus Dupuytren, Viking disease, and Celtic hand) is a condition in which one or more fingers become permanently bent in a flexed position. Compared with 500 random samples of 21 SNPs taken from across the genome, the DD-associated SNPs do not show an increase in within-population structure (p = 0.072, Figure 2(a)), which would have been expected had DD been associated with Norse ancestry. Dupuytren’s disease (DD) is an ancient affliction of unknown origin. Fiche de conseils Dupuytren. If DD were of Norse origin, we would expect that the total FST of our disease-associated SNPs would be higher than randomly generated groups of SNPs. This product could help you, Accessing resources off campus can be a challenge. The most commonly used measure of genetic difference between populations is Wright’s Fixation Index (FST) (Hudson et al., 1992). If DD were of Norse origin, we would expect that cases would have a higher average total FST than controls. The first nickname comes from the belief that the condition originated among the Vikings (inhabitants in Scandinavian countries: Denmark, Norway, and Sweden). First, epidemiological studies have shown that DD is more common in European populations and the prevalence seems to be highest in Iceland and Scandinavian countries that were the origin of the Viking Warriors (Hindocha et al., 2009). It has been suggested that Dupuytren’s disease has an origin in Norse countries. Wright’s Fixation Index (FST) analysis reveals no evidence of a Norse origin of Dupuytren’s Disease (DD). It usually begins with a small lump, called a nodule, in the palm or fingers that is often mistaken for a blister or callus. The GRS for DD from the 21 independent Dupuytren’s GWAS hits was calculated for each individual in the PoBI dataset. Lactase is under positive selection and therefore is expected to show much less population-specific haplotype sharing, and is therefore a positive control in this analysis. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} La maladie de Dupuytren est caractérisée par une rétraction des doigts secondaire à une prolifération de tissu fibreux rétractile dans l’aponévrose palmaire et ses prolongements dans les doigts. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). Compared with previous reports (Whaley and Elliot, 1993), our data provide objective evidence of the lack of Norse origin of the disease. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." If the most highly associated SNP from a credible set was not present in the PoBI dataset, we searched sequentially for the next most associated SNP, continuing until a representative variant was found, or all variants in a 99% credible set were exhausted. There are three major historical sources of this population structure: north-west Germany, France and Spain, with the greatest contribution observed in the current population of rural Wales; northern Germany and Denmark, with the greatest contribution observed in the population of rural south-east England; and the Norse, with the greatest contribution observed in the population of the Orkney Islands. For five credible sets, there was no representative SNP in the PoBI dataset (lead SNPs: rs117402009, rs2472141, rs1042704, rs61982174, rs34088184), meaning there were 21 DD-associated SNPs remaining for analysis. However, there are nine or ten different genes associated with Dupuytren’s and this suggests that it may have evolved on several different occasions. La maladie de Dupuytren est une maladie d`origine inconnue qui. The earliest reference that we found in the medical literature to the condition that ultimately came to be known as Dupuytren’s Disease was a report by Felix Plater in the 17 th century. To date, genome-wide association studies (GWAS) have revealed 26 loci predisposing to DD (Dolmans et al., 2011; Ng et al., 2017). Part 1: the origin of the disease: the curse of the MacCrimmons: the hand of benediction: Cline's contracture, The Vikings and Baron Dupuytren's disease, Isolated populations as treasure troves in genetic epidemiology: the case of the Basques, Quelques aspects epidemiologiques de la maladie de Dupuytren, Clinical associations of Dupuytren's disease, Epidemiological evaluation of Dupuytren's disease incidence and prevalence rates in relation to etiology, Estimation of levels of gene flow from DNA sequence data, Inference of population structure using dense haplotype data, The fine-scale genetic structure of the British population, A genome-wide association study of Dupuytren disease reveals 17 additional variants implicated in fibrosis, A weighted genetic risk score predicts surgical recurrence independent of high-risk clinical features in Dupuytren's disease, Genetic architecture: the shape of the genetic contribution to human traits and disease. Total FST of the remaining 21 DD-associated SNPs was calculated, using each of the three comparator groups. La maladie de Dupuytren atteint 216 d’entre eux, soit une prévalence de 7,1%. En règle générale, la quantité d’alcool consommée (volume, fréquence et durée) détermine le risque et la gravité des lésions hépatiques. For the case-control analysis, the total genomic FST was calculated for each individual case or control using the formula: Second, the total FST of the DD-associated SNPs from BSSH-GODD was calculated and compared with the total FST of 10,000 randomly generated permutations of SNP groups of the same size, to generate an empirical p-value for the ‘Viking origin’ of DD-associated SNPs. Elle entraîne une rétraction et une flexion progressive et irréductible des doigts. Cette maladie est en partie d’origine génétique et apparaît le plus souvent vers la cinquantaine chez l’homme et plus tardivement chez la femme. This site uses cookies. In Orkney vs Wales, the DD-associated set was on the 74th centile; in Orkney vs South East, it was on the 81st centile; and in Orkney vs Wales and South East, it was on the 92nd centile. Le travail prolongé avec les mains n’est pas responsable de la maladie de Dupuytren. ]}. La maladie de Dupuytren et le syndrome du canal carpien peuvent survenir chez le même patient. http://www.creativecommons.org/licenses/by/4.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, https://www.hsph.harvard.edu/alkes-price/software/, Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren’s disease, Radiotherapy in Dupuytren’s disease: a systematic review of the evidence, Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. Dupuytren’s disease (DD) is a disease of the palmar fascia that causes flexion contractures of the fingers (Townley et al., 2006). Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711 . View or download all the content the society has access to. Viking legacy makes a great story. Affections associées. However, it is referred to by commons as Viking disease. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d'abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Some scepticism as to the Norse origin of the disease has been expressed by Elliot (1988). FST for each SNP was calculated using Hudson’s estimator of FST (Hudson et al., 1992), as implemented in EIGENSOFT (https://www.hsph.harvard.edu/alkes-price/software/). This work was supported by the NIHR Biomedical Research Centre, Oxford. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: DF was supported by an Intermediate Clinical Fellowship from the Wellcome Trust [097152/Z/11/Z]. In: Mcfarlane RM MD, Flint MH (Eds). La Société canadienne de Dupuytren est présentement à la recherche d’un membre pour se joindre à notre comité de levée de fonds La société canadienne Dupuytren a été constituée et a reçu le statut d'organisme de bienfaisance en 2015. La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. L’analyse statistique a été faite sur logiciel Epi info et SPSS. Local haplotype structure does not support a Viking introgression of Dupuytren’s disease into the British Isles. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Le travail manuel n’est pas responsable de la maladie de Dupuytren. Causes et facteurs de risque de la maladie de Dupuytren. De quoi parle t-on ? I’ve counted 113 medical journal articles published since 1985 which associate Dupuytren with the Vikings. D’autres pathologies d’altération de gènes responsables de dégradation du collagène ont été également retrouvées. Dupuytren’s disease (DD) is an ancient affliction of unknown origin. Une prédisposition héréditaire est souvent retrouvée. La maladie de Dupuytren est pratiquement inexistante en Afrique et en Asie. Garagnani, P, Laayouni, H, Gonzalez-Neira, A. Gebereegziabher, A, Baraki, A, Kebede, Y, Mohammed, I, Finsen, V. Lawson, DJ, Hellenthal, G, Myers, S, Falush, D. Timpson, NJ, Greenwood, CMT, Soranzo, N, Lawson, DJ, Richards, JB. It is named after Guillaume Dupuytren, who first described the underlying mechanism of action followed by the first successful operation in 1831 and publication of the results in The Lancet in 1834. He also makes reference to both the ‘fragmentary nature of the record which has survived’ and the fact that life expectancy in previous centuries was much lower than the median age of onset of DD; these are both pertinent points that reveal the weakness of the historical case. Lactase is under positive selection and therefore has much less population-specific haplotype sharing. Linear regression analysis of hospital episode statistics predicts a large increase in demand for elective hand surgery in England, Effects of vibration on the hand-arm system of miners in India, The early history of contracture of the palmar fascia. English new terms dictionary; Interpretations; Translations; Books; English new terms dictionary  Dupuytren's contracture. Origin C19: named after the French surgeon Baron Guillaume Dupuytren. La maladie se manifeste surtout après la quarantaine et toucherait 6 fois plus souvent un homme qu’une femme. Exceptionnelle chez les Asiatiques (1 seul cas), les Africains (à peine 8 cas répertoriés) et les Indiens (10 cas décrits) , la maladie de Dupuytren survient seulement chez les sujets blancs, européens du nord (Islande, Scandinavie, Russie, Angleterre) et chez leurs descendants, en particulier dans les pays d'émigration britannique (Canada, États-Unis, Australie). In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. La prédisposition génétique de cette maladie est actuellement établie de façon irréfutable. La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Lore has it that they spread it throughout northern Europe. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease.